Sample enrichment (cleanup) using dual precolumns

Sample is injected by a separate injector onto one of two precolumns (stripper). Early eluting components vent at port 6 while components of interest are retained on the stripper. When the valve is switched, a new injection is made onto the second stripper while components retained on the first stripper are backflushed onto the analytical column at port 9. This method requires an auxiliary pump at port 4.

Click below to change the valve position. (Currently shown in Position A)

A: Early-eluting components are vented,
components of interest retained on precolumn 1

Position A

B: Components of interest sent to analytical column,
new injection repeats the process with precolumn 2

Position B